Depletion of tryptophan is not involved in expression of tryptophanyl-tRNA synthetase mediated by interferon.
AUTOR(ES)
Flohr, T
RESUMO
Gamma interferon (IFN-gamma) affects tryptophan metabolism by mediating the expression of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase. In the present study, we investigated the role of indoleamine 2,3-dioxygenase-mediated tryptophan depletion in the induction of tryptophanyl-tRNA synthetase by IFN-gamma. The addition of excess tryptophan to the culture medium did not affect the induction of tryptophanyl-tRNA synthetase by IFN-gamma, indicating that tryptophan degradation is not directly involved in the IFN-gamma-mediated expression of tryptophanyl-tRNA synthetase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=257482Documentos Relacionados
- Regulation of tryptophanyl-tRNA synthetase formation.
- Overproduction of tryptophanyl-tRNA synthetase relieves transcription termination at the Escherichia coli tryptophan operon attenuator.
- The "eRF" clone corresponds to tryptophanyl-tRNA synthetase, not mammalian release factor.
- The effect of tRNA and tryptophanyl adenylate on limited proteolysis of beef pancreas tryptophanyl-tRNA synthetase.
- Mammalian polypeptide chain release factor and tryptophanyl-tRNA synthetase are distinct proteins.