Depression of the antibody response in Pseudomonas aeruginosa-injected mice.
AUTOR(ES)
Garzelli, C
RESUMO
Heat-killed Pseudomonas aeruginosa inhibit antibody response in C57BL/6 mice. The depression of this response is dependent on the dose of bacteria injected, on the time interval between microorganism injection and antigen administration, and on the nature of the antigen used. Cell transfer experiments provide evidence that suppressor cells are not operative in this model. Furthermore, the results show that P. aeruginosa induces a marked dose-dependent proliferation of spleen cells in vivo, and the in vitro targets of this proliferative effect are B lymphocytes. It is suggested that whole, heat-killed P. aeruginosa in vivo also behave as cell mitogens on B lymphocytes which, when strongly stimulated to proliferate, temporarily lose their capacity to mount a normal antibody response.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414257Documentos Relacionados
- Depression of contact sensitivity by enhancement of suppressor cell activity in Pseudomonas aeruginosa-injected mice.
- Depression of contact sensitivity and enhancement of antibody response in Pseudomonas aeruginosa-infected mice.
- Effect of cyclophosphamide on the immune response to Pseudomonas aeruginosa in mice.
- Passage of Pseudomonas aeruginosa in compromised mice.
- Antibody response of infected mice to outer membrane proteins of Pseudomonas aeruginosa.
