Derivative spectrophotometric determination of vitamin B6 in pharmaceutical preparations / Doseamento da vitamina B6 por espectrofotometria derivada no ultravioleta

AUTOR(ES)

Vladi Olga Consiglieri

DATA DE PUBLICAÇÃO

1992

RESUMO

A rapid and selecrive method for rhe dererminarion of pyridoxine in pharmaceuticals has been described. The procedure has been developed using direct UV first-derivative spectrofotometry in solid and liquid preparations (tablets, oral solution and injection). Spectral inrerferences from formulation excipienrs and other drugs in simple UV spectrophotometric methods have been eliminated by the application of the proposed method. Calibration curves have been made and the correlation coefficienr for. the first-order derivative was 0,99997. Standard deviation, coefficient of variation and confidence interval were calculated. The method was applied in the analysis of commercial and simulated samples. The results when compared with those obtained by using the USP 22nd. ed. official method shows clear advanrages related to accuracy, precision and practical application.

ASSUNTO(S)

vitamina b6 vitamin b6 drug analysis piridoxina pyridoxine fármacos espectrofotometria spectrophotometry

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