Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.

AUTOR(ES)

Dempcy, R O

RESUMO

Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].

Documentos Relacionados

• Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.
• Design of RNA enzymes distinguishing a single base mutation in RNA.
• Chemical synthesis of branched RNA.
• In vitro synthesis of infectious retroviral RNA.
• In vitro synthesis of infectious poliovirus RNA.