Detailed Analysis of the CD8+ T-Cell Response following Adenovirus Vaccination

AUTOR(ES)

Yang, Teng Chih

FONTE

American Society for Microbiology

RESUMO

We examined CD8+ T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8+ T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8+ T-cell response.

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