Detection of Nonspecific Resistance to Listeria monocytogenes in Rabbits Infected with Treponema pallidum
AUTOR(ES)
Schell, Ronald F.
RESUMO
Several lines of evidence suggest that cell-mediated immunity (CMI) is suppressed in the early stages of infection caused by Treponema pallidum and becomes activated at the time that latency is induced. In the studies reported in this paper, rabbits were infected intravenously with T. pallidum and subsequently challenged with Listeria monocytogenes. Enhanced ability to suppress the growth of Listeria was detected in their livers between 3 and 5 weeks after infection with T. pallidum, corresponding to the onset and regression of the generalized syphilitic eruption. A second infection of T. pallidum 4 weeks after the first, at a time when suppression was beginning to wane, prolonged the listericidal activity. These observations support the hypothesis that infection by T. pallidum stimulates CMI, which, in turn, may play a role in inducing latency.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414861Documentos Relacionados
- Susceptibility of rabbits venereally infected with Treponema paraluis-cuniculi to superinfections with Treponema pallidum.
- Sequential changes in susceptibility to Treponema pallidum of rabbits previously infected with Treponema paraluis-cuniculi
- Secondary lesions in rabbits experimentally infected with Treponema pallidum.
- Depression of lymphocyte response to concanavalin A in rabbits infected with Treponema pallidum (Nichols strain).
- Selective response of lymphocytes from Treponema pallidum-infected rabbits to mitogens and Treponema reiteri.
