"Determinação do perfil de expressão dos RNAs mensageiros da família das Smads e dos componentes do complexo AP-1 em carcinoma de célula escamosa de cabeça e pescoço" / Smads and AP-1 messenger RNA expression pattern in Head and Neck Squamous Cell Carcinoma

AUTOR(ES)

Flavia Regina Rotea Mangone

DATA DE PUBLICAÇÃO

2005

RESUMO

Smad and AP1 messenger RNA expression may underlie disruptions affecting TGFb signaling in head and neck squamous cell carcinoma (HNSCC). Analysis of Smads1-8 mRNA expression by RPA has shown Smad expression is globally increased in tumor as compared to adjacent normal tissue. Kaplan Meier survival curves and multivariate analysis revealed that Smad6 positivity in tumor was an independent good prognostic factor in HNSCC. In relation to AP-1, as measured by Northern blot, only Fra-1 was overexpressed in tumor and directly related to the presence of lymph node involvement. Our data suggest that Smad6 may be a marker of good prognosis in HNSCC

ASSUNTO(S)

neoplasias de cabeÇa e pescoÇo/fisiopatologia rna mensageiro rna messenger transcription factor ap 1 carcinoma squamous cell/physiopathology northern blotting/métodos nuclease protection assays/methods fatores de transcriÇÃo carcinoma de cÉlulas escamosas/fisiopatologia head and neck neoplasm/physiopathology transforming growth factor beta blotting northern/methods fator de crescimento transformador beta transcription factors fatores de transcriÇÃo ap 1 ensaios de proteÇÃo de nucleases/métodos

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