Determinação e modulação da excitabilidade cortical pela estimação magnética transcraniana

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

15 In the present study, we performed rTMS in five patients with intractable epilepsy, recording the number of daily seizures during 3 months before treatment, 3 months of treatment with bi-weekly rTMS sessions, and for 3 months after treatment. We have found a mean reduction of 22% in the number of daily seizures, during the period of treatment (range: 9.23 % to 43.09%). This reduction was statistically significant, although 2 of the 5 patients did not experience any reduction in the mean daily number of seizures. These findings demonstrate that there is a significant effect of rTMS in reducing cortical hyper-excitability in epileptics. In another study, we used rTMS to treat intractable depression in 3 patients. Patient 1 had severe psychotic depression (Hamilton score=38), and did not benefit from rTMS. Patient 2 also had psychotic symptoms, and there was a 50% reduction in her depression score, although she still had mild depression after treatment. The third patient, without psychotic symptoms, had moderate depression (score=22) and had significant improvement (final score=2). We suggest that slow- frequency rTMS is a safe adjunctive treatment for depression. Our third study aimed at using TMS to compare manual dexterity and motor cortex excitability for the healthy hand of hemiplegic patients. We have found significant motor deficits in the unaffected hand of hemiplegics; moreover, this was associated with an increased motor threshold of the healthy cerebral hemisphere.

ASSUNTO(S)

depressão mental acidente vascular encefálico ciencias da saude hemiplegia epilepsia

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