Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

AUTOR(ES)

Nader, H.B., Pinhal, M.A.S., Baú, E.C., Castro, R.A.B., Medeiros, G.F., Chavante, S.F., Leite, E.L., Trindade, E.S., Shinjo, S.K., Rocha, H.A.O., Tersariol, I.L.S., Mendes, A., Dietrich, C.P.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2001-06

RESUMO

The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.

Documentos Relacionados

• Matrix-driven translocation: dependence on interaction of amino-terminal domain of fibronectin with heparin-like surface components of cells or particles.
• A puerperal haemorrhagic state due to a heparin-like anticoagulant
• Mass spectrometric and capillary electrophoretic investigation of the enzymatic degradation of heparin-like glycosaminoglycans
• Evaluation of blood compatibility of plasma deposited heparin-like films and SF6 plasma treated surfaces
• Heparin-Like Structures on Respiratory Syncytial Virus Are Involved in Its Infectivity In Vitro