Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?
AUTOR(ES)
Reusch, Jane E.B.
FONTE
American Society for Clinical Investigation
RESUMO
Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=198532Documentos Relacionados
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