Diagnostic value of the serum folate assay

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RESUMO

The diagnostic value of the serum folate assay has been assessed in 90 patients, each of whom had a macrocytic anaemia and a low serum vitamin B12 level. Twenty-nine (32%) patients were found to have anaemia due primarily to folate deficiency. The cause of the low serum vitamin B12 levels is uncertain in the 22 (25%) patients with normal or borderline vitamin B12 absorption. The effect of folic acid therapy was studied in four of these patients, and in each case the serum vitamin B12 rose slowly to a normal level.

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