Differential effect of nucleoside analog triphosphates on ribonucleotide reductases from uninfected and herpes simplex virus-infected HeLa cells.
AUTOR(ES)
Nakayama, K
RESUMO
Effects of the triphosphates of eight pyrimidine nucleoside analogs (5-substituted, 2'-fluoroara-, and acyclonucleosides) and acycloguanosine were examined on the ribonucleotide reductases prepared from uninfected and herpes simplex virus (types 1 and 2)-infected HeLa cells. Of the analogs tested, E-5-propenyl- and E-5-(2-bromovinyl)-dUTP were more potent inhibitors than dTTP of the enzymes from virus-infected cells, whereas only the former compound showed this effect on the uninfected HeLa enzyme.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=256123Documentos Relacionados
- Properties of DNA ligase from uninfected and virus-infected HeLa cells.
- Synthesis of viral and host DNA in isolated chromatin from herpes simplex virus-infected HeLa cells.
- Glycosylation of vesicular stomatitis virus glycoprotein in virus-infected HeLa cells.
- Synthesis of polynucleotide 5'-triphosphatase in vaccinia virus-infected HeLa cells.
- Virus-Specific Proteins Synthesized in Encephalomyocarditis Virus-Infected HeLa Cells
