Differential Monocyte Activation Underlies Strain-Specific Mycobacterium tuberculosis Pathogenesis
AUTOR(ES)
Manca, Claudia
FONTE
American Society for Microbiology
RESUMO
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.
