Distribution and Fate of Synthetic Lipid Vesicles in the Mouse: A Combined Radionuclide and Spin Label Study
AUTOR(ES)
McDougall, I. R.
RESUMO
Single compartmental spherules of various lipid constituents (vesicles), enclosing 99mTcO4- as a radioactive marker, were injected intravenously into C3H mice, and the distribution of radioactivity was studied. About 25% of the administered radioactivity was present in the liver 5 min and 30 min after the injection of vesicles composed of phosphatidylcholine and gangliosides, which were sonicated for 5 min (standard preparation). About 10-20% of the radioactivity remained in the circulation. By use of a nonradioactive spin label (tempocholine) enclosed within vesicles, intact vesicles were demonstrated in the circulation for 46 min after intravenous injection. The distribution of radioactivity from 99mTcO4- inside vesicles is very different from that of free 99mTcO4- or of 99mTc sulfur colloid.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=433799Documentos Relacionados
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