DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis
AUTOR(ES)
Durbach, Steven I.
FONTE
American Society for Microbiology
RESUMO
One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N′-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting that permeation of nitrosative stress to the level of cytotoxic DNA damage is restricted.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145403Documentos Relacionados
- Regulation of hmp Gene Transcription in Mycobacterium tuberculosis: Effects of Oxygen Limitation and Nitrosative and Oxidative Stress
- noxR3, a Novel Gene from Mycobacterium tuberculosis, Protects Salmonella typhimurium from Nitrosative and Oxidative Stress
- In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.
- Reversal of DNA alkylation damage by two human dioxygenases
- Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress