DNA double-strand break repair functions defend against parvovirus infection.
AUTOR(ES)
Tauer, T J
RESUMO
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=190677Documentos Relacionados
- SMC1 coordinates DNA double-strand break repair pathways
- Evidence for Conservative (Two-Progeny) DNA Double-Strand Break Repair
- Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair
- DNA double-strand break repair: genetic determinants of flanking crossing-over.
- Distinct functions of BRCA1 and BRCA2 in double-strand break repair
