Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?
AUTOR(ES)
Foy, P M
RESUMO
A total of 276 patients with a high risk of developing postoperative seizures were randomised to treatment with carbamazepine or phenytoin for six or 24 months, or to no treatment. No significant differences were found (though the confidence limits were fairly wide) between the regimes in respect of the incidence of seizures or death. In a substantial proportion of the patients postoperative epilepsy remained a continuing disability. A high incidence of drug-related side effects was found in the treatment groups. Prophylactic anticonvulsants cannot therefore be recommended routinely following supratentorial craniotomy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1015096Documentos Relacionados
- Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
- Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function.
- Do drugs alter the course of rheumatoid arthritis?
- Prophylactic drug management for febrile seizures in children
- Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures