Dominant and specific repression of Xenopus oocyte 5S RNA genes and satellite I DNA by histone H1.
AUTOR(ES)
Wolffe, A P
RESUMO
The genome of Xenopus laevis contains two large families of class III genes (oocyte 5S RNA and satellite I DNA) that are repressed in somatic cells. Both gene families are actively transcribed in a soluble extract of X.laevis oocyte nuclei, using chromatin deficient in histone H1 as a template. The addition of histone H1, to this transcriptionally active chromatin, results in the dominant and selective repression of oocyte 5S RNA genes and satellite I DNA. Somatic 5S RNA genes remain active following histone H1 addition. Changes in chromatin structure could have a dominant role in the regulation of class III gene expression during Xenopus embryogenesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400838Documentos Relacionados
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