Dosage Compensation Regulatory Proteins and the Evolution of Sex Chromosomes in Drosophila
AUTOR(ES)
Bone, J. R.
RESUMO
In the fruitfly Drosophila melanogaster, the four male-specific lethal (msl) genes are required to achieve dosage compensation of the male X chromosome. The MSL proteins are thought to interact with cis-acting sites that confer dosage compensation to nearby genes, as they are detected at hundreds of discrete sites along the length of the polytene X chromosome in males but not in females. The histone H4 acetylated isoform, H4Ac16, colocalizes with the MSL proteins at a majority of sites on the D. melanogaster X chromosome. Using polytene chromosome immunostaining of other species from the genus Drosophila, we found that X chromosome association of MSL proteins and H4Ac16 is conserved despite differences in the sex chromosome karyotype between species. Our results support a model in which cis-acting regulatory sites for dosage compensation evolve on a neo-X chromosome arm in response to the degeneration of its former homologue.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1207561Documentos Relacionados
- Model for evolution of Y chromosomes and dosage compensation.
- Incomplete dosage compensation in an evolving Drosophila sex chromosome.
- RNA Binding Protein Sex-Lethal (Sxl) and Control of Drosophila Sex Determination and Dosage Compensation
- Sex determination and dosage compensation in Drosophila melanogaster: production of male clones in XX females
- Differential Effects of Sex-Lethal Mutations on Dosage Compensation Early in Drosophila Development