Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil

AUTOR(ES)

Pereira, Polyana Silva, Albano, Rodolpho Mattos, Asensi, Marise Dutra, Carvalho-Assef, Ana Paula D’Alincourt

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

29/05/2015

RESUMO

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri(CCBH11880), Enterobacter hormaecheisubsp. oharae(CCBH10892) and Klebsiella pneumoniae(CCBH13327), isolated in Brazil. BesidesblaNDM-1, resistance genes to aminoglycosides [aadA1, aadA2,aac(6’)-Ib-cr] and quinolones (qnrA1,qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to theblaNDM-1 gene in all strains.

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