Dual-Action Cephalosporin Utilizing a Novel Therapeutic Principle
AUTOR(ES)
Greenwood, D.
RESUMO
A new cephalosporin is described that overcomes, in a novel way, the general susceptibility of this group of agents to enterobacterial β-lactamases. The new compound carries a substituent that is released on cleavage of the β-lactam ring and then exhibits antibacterial activity in its own right. The possible therapeutic benefits of such an antibiotic are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429730Documentos Relacionados
- Mode of action of the dual-action cephalosporin Ro 23-9424.
- Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals.
- Single-Action Versus Dual-Action Antidepressants
- In vitro activity of Ro 23-9424, a dual-action cephalosporin, compared with activities of other antibiotics.
- In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents.
