Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.

AUTOR(ES)

Mett, H

RESUMO

We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.

Documentos Relacionados

• Innate Antimicrobial Activity of Nasal Secretions
• Inhibitory capacity of alpha 1 antitrypsin in lung secretions: variability and the effect of drugs.
• Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.
• Semiautomated assessment of in vitro activity of potential antileishmanial drugs.
• Bactericidal activity of antimicrobial agents for treponemes.