Early breakdown of the blood-retinal barrier in diabetes.
AUTOR(ES)
Cunha-Vaz, J.
RESUMO
The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1017427Documentos Relacionados
- Studies on the permeability of the blood-retinal barrier. II. Breakdown of the blood-retinal barrier by injury.
- Studies on the permeability of the blood-retinal barrier. 3. Breakdown of the blood-retinal barrier by circulatory disturbances.
- Studies on the permeability of the blood-retinal barrier. I. On the existence, development, and site of a blood-retinal barrier.
- Increased Intraocular Insulin-like Growth Factor-I Triggers Blood-Retinal Barrier Breakdown*
- The Blood-Retinal Barriers