Early nerve-muscle synapses in vitro release transmitter over postsynaptic membrane having low acetylcholine sensitivity.
AUTOR(ES)
Cohen, S A
RESUMO
Functional nerve-muscle synapses form rapidly in cultures of embryonic chicken spinal cord and muscle cells. As early as 30 min after nerve processes first contact muscle fibers they are able to release stimulus-evoked neurotransmitter. This release was detected only after wave-form averaging because of the exceedingly low amplitude of the synaptic potentials. This small size was likely due to a postsynaptic effect, because the electrophysiologically assayed acetylcholine sensitivity of the synaptic muscle membrane was low and did not differ significantly from extrasynaptic levels. Transmitter release was elicited both from along the lengths of nerve processes and from active growth cones.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348331Documentos Relacionados
- Nerve-Muscle Interaction
- The subsynaptic 43-kDa protein is concentrated at developing nerve-muscle synapses in vitro.
- The action of serotonin on excitatory nerve terminals in lobster nerve-muscle preparations.
- Initial synaptic transmission at the growth cone in Xenopus nerve-muscle cultures.
- Neuromuscular activity of Bothrops neuwiedi pauloensis snake venom in mouse nerve-muscle preparations