Ecological Effects of Perorally Administered Pivmecillinam on the Normal Vaginal Microflora
AUTOR(ES)
Sullivan, Åsa
FONTE
American Society for Microbiology
RESUMO
The knowledge of the effects of antimicrobial agents on the normal vaginal microflora is limited. The objective of the present study was to study the ecological impact of pivmecillinam on the normal vaginal microflora. In 20 healthy women, the estimated day of ovulation was determined during three subsequent menstrual cycles. Microbiological and clinical examinations were performed on the estimated day of ovulation and on day 3 in all cycles and also on day 7 after ovulation in cycles 1 and 2. Anaerobic and facultative anaerobic gram-positive rods, mainly species of lactobacilli and actinomycetes, dominated the microflora. One woman was colonized on the third day of administration with a resistant Escherichia coli strain, and Candida albicans was detected in one woman on days 3 and 7 in cycle 2. No other major changes in the normal microflora occurred during the study. Administration of pivmecillinam had a minor ecological impact on the normal vaginal microflora.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=538917Documentos Relacionados
- Effect of perorally administered lactobacilli on macrophage activation in mice.
- Influence of intravenously administered ciprofloxacin on aerobic intestinal microflora and fecal drug levels when administered simultaneously with sucralfate.
- Relationship of Vaginal Cytology to Alterations of the Vaginal Microflora of Rats During the Estrous Cycle
- Spatial relationship of the vaginal microflora to the vaginal epithelium of female rats: scanning electron microscopy.
- Effects of Systemic Demethylchlortetracycline on Human Cutaneous Microflora
