EFEITO DA DIACEREÍNA SOBRE A FEBRE INDUZIDA POR SUSPENSÃO DE Saccharomyces cerevisiae E POR PROSTAGLANDINA E2 EM RATOS JOVENS. / EFFECT OF DIACEREIN ON BAKER YEAST- AND PROSTAGLANDIN E2-INDUCED FEVER IN YOUNG RATS.
AUTOR(ES)
Juliana Saibt Martins Pasin
DATA DE PUBLICAÇÃO
2005
RESUMO
Fever is a systemic response that results of a cascade of events that usually begins with pathogenic infection. Its development represents an important aspect of host defense that is mediated by the central nervous system. However, antipyretic medication are routinely prescribed because fever is associated with discomfort and anxiety, apart from to represent a iminent risk of febrile seizures. The present study aimed to investigate the effect of diacerein on body temperature and Bakers Yeast- and prostaglandin E2 -induced fever in young male Wistar rats (28 30 days of age). The subcutaneous administration of diacerein (5mg/kg) did not alter basal rectal temperature. This dose attenuated the febrile response induced by Baker Yeast, however did not reversed prostaglandin E2 -induced fever. Moreover, diacerein (5mg/kg, s.c.) delayed the onset of fever induced by Baker Yeast, but it did not prevent their installation. Interestingly, diacerein inhibited the leukocyte migration enhancement that occurred in the control group after the intraperitoneal administration of Bakers Yeast. These data suggest that the diacerein exert a weak antipyretic effect, which may occur through inhibition of synthesis of proinflammatory cytokines. However, further studies are needed to elucidate the precise mechanism of this antipyretic action of diacerein.
ASSUNTO(S)
baker yeast diacereína febre bioquimica diacerein antipiréticos saccharomyces cerevisiae fever antipyretics
ACESSO AO ARTIGO
http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1659Documentos Relacionados
- PADRONIZAÇÃO E VALIDAÇÃO DE UM NOVO MODELO DE FEBRE INDUZIDA PELA INJEÇÃO INTRATECAL DE PROSTAGLANDINA E2 EM RATOS JOVENS
- PROSTAGLANDIN E2 POTENTIATES METHYLMALONATE-INDUCED SEIZURES
- Prostaglandin E2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats.
- Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.
- Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.