Efeito da pinealectomia na remodelação do osso alveolar de ratos submetidos à movimentação ortodôntica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Melatonin participates in a wide variety of physiological functions, including sleep induction, gastrointestinal activity, immune defense response, cardiovascular function, renal function and reproduction. This hormone also has effect in bone physiology, modulating osteoblasts and osteoclast activity. The aim of this study was to evaluate the involvement of melatonin on rat alveolar bone remodeling submitted to orthodontic treatment. Ten male Wistar rats were submitted to cryoanesthesia and pinealectomized or sham operated at five days of birthday. At 120 days of age, the animals were anesthetized with thiopental sodium and the orthodontic appliances (NiTi coil) were fixed between first molar and incisor teeth using an adhesive resin. After fifteen days of orthodontic treatment the animals were sacrificed by exposition to a saturated anesthetic ether vapor environment. The maxillas were dissected, fixed with formaldehyde 10%, decalcified with nitric acid, dehydrated and embedded in paraffin. Transversal sections of cervical, medium and apical first molar root were analyzed. Morphological analysis showed greater alveolar bonde destruction of pinealectomized rats pinealectomized submitted to orthodontic treatment compared to control group. The results suggest that melatonin plays an important role in alveolar bone remodeling of rats submitted to the orthodontic treatment probably stimulating osteoblasts action and bone formation. Also, the melatonin also exerts an inhibitory effect on osteoclasts activity and it causes greater bone reabsorption in pinealectomized rats

ASSUNTO(S)

anatomia patologica e patologia clinica ortodontia glandula pineal melatonina

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