Efeito da radiação gama no processo de reparação ossea em ratas com deficiencia de estrogenio

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

As osteoporosis is a condition that causes bone fragility and ionization radiation makes the repair process difficult, the experiment was carried out to check the effect of the association of estrogen deficiency and ionization radiation on the bone repair process. The 4 experimental groups of female Wistar rats were subjected to the following conditions: control, ovariectomized, irradiated and ovariectomized/irradiated, with estrogen deficiency being induced through ovariectomy. After estrogen deficiency was confirmed, all the animals in the ovariectomized groups had a bone defect made in their tibias. The irradiated groups and ovariectomized/irradiated had their inferior members irradiated with 8 Gy of gama radiation 3 days after the surgical procedure. After 7, 14, 21, 28 and 45 days had elapsed, the bone repair process was evaluated, Hematoxylin-Eosin and Mallory?s Tricomic being used for the morphologic evaluation. The following analyses were also carried out: birefringence analysis (Picrosirius Stain); the volumetrical density analysis (hematoxylin-eosin stain) and the ultra-structural analysis (Electronic Scanning Microscopy). The results found indicated that there was delay in the repair process in the ovariectomized/irradiated group, in which the association of the estrogen deficiency and ionization radiation caused a decrease in the production of neo- formed bone and accelerated the reabsorption process

ASSUNTO(S)

ossos - defeitos osteoporosis bones ovariectomia ovariectomy osteoporose

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