Efeito do meloxicam sobre o extravasamento plasmatico induzido pelo oleo de mostarda na ATM de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

1999

RESUMO

Little is known about the mechanism(s) involved in both initiation and maintenance of inflammation and inflammation - related pain within the temporomandibular joint (TMJ). Thus, HASS et aI. (1992), developed an orofacial model of acute inflammation in the rat. They showed that application of the small fiber excitant and inflammatory irritant mustard oil (MO) to the temporomandibular joint (TMJ) induces plasma protein xtravasation. However, relatively little is known about the contribution of eicosanoids (prostaglandins) to the plasma protein extravasation induced by MO. The purpose of this study was to test the effect of intraperitoneal (IP) administration of meloxicam on the plasma protein extravasation induced by MO. Inflammation was induced, in three indiyidual groups, by the intra-articular administration of 20 JlI of 20%, 2,5% and 0,5% MO, respectively. Plasma protein extravasation was measured by the Evans blue method. Meloxicam or saline (control) were given (IP) 2 hours before the administration of MO. Even in high dose (22 mg/kg), meloxicam did not have inhibitory effect on the protein plasma extravasation induced by 20% and 2,5% MO. On the other hand, when the inflammation was induced by 0,5% MO, the pretreatment with meloxicam induced a significant (p<0,05) reduction in the plasma protein extravasation (mean :I:: S.E.M; 27,85 ::I: 3,94) compared with the control (43,21 ::I: 4,84).These results demonstrated that 1) 0,5% MO is more appropriate than 20% or 2,5% to the study of anti-inflammatory drugs in this model of inflammation and that 2) prostaglands are involved in the MO-induced protein plasma extravasation

ASSUNTO(S)

agentes antiinflamatorios articulação temporomandibular

ACESSO AO ARTIGO

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