Efeito do tratamento com novos derivados imidazolidÃnicos e praziquantel sobre os lipÃdios de camudongos infectados por Schistosoma mansoni

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The Schistosomiasis mansoni is the second human parasitosis more prevalent in the world, being in Brazil a problem of public health. The schistosomiasis alters lipid metabolism, promoting decrease in plasma levels of total cholesterol (TC), total phospholipids (TF) and triglycerides (TG). The praziquantel (PZQ) is the principal agent schistosomicidal employed for the treatment. However, the apparition of resistant strains to the conventional treatment encourage the development of new anti‐schistosomal drugs. In this context, the imidazolidines comes detaching like drugs with potential anti‐schistosomal activity front of S. mansoni in vitro and in vivo. This work aimed to evaluated the effect of treatment, at concentrations of 50mg/kg/day and 100mg/kg/day of imidazolidine derivatives 3‐benzyl‐5‐ (4‐chloro‐arylazo)‐4‐thioxo‐imidazolidin‐2‐one (LPSF‐PT5), 3‐(4‐chloro‐benzyl)‐5‐(4nitrobenzylidene)‐ imidazolidine‐2,4‐dione (LPSF‐FZ4) and PZQ on lipid metabolism of schistosomiasis mansoni infected and uninfected mice. The results showed that in infected mice, treatment with 100mg/kg/day PZQ and LPSF‐PT5 significantly reduced plasma TC levels by 24.59% and by 18.60%, respectively as well TG level by 31.60% e 31.50%, respectively fact possibly justified for schistosomiasis effect in the animal. At dose of 50 mg/kg/day and 100 mg/kg/day, LPSF‐FZ4 induced significant decrease by 44.80% and by 40.30% on TG levels from S. mansoni mice, respectively. On the other hand, uninfected animals treated with 50 mg/kg/day and 100 mg/kg/day LPSF‐FZ4 presented about 26.9% and 21.7% significant decreases on plasma TG level. Therefore, analyzing the alterations in vivo of plasma lipids evaluated, imidazolidine derivative LPSF‐FZ4 represented the compound with better potential hypotrigliceridemic

ASSUNTO(S)

olesterol total atividade hipotrigliceridemia praziquantel bioquimica derivados imidazolidÃnicos esquistossomose mansÃnica

ACESSO AO ARTIGO

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