EFFECT OF 5-BROMODEOXYURIDINE ON EXPRESSION OF CULTURED CHONDROCYTES GROWN in vitro*
AUTOR(ES)
Holthausen, H. Schulte
RESUMO
Exposure of cultured cartilage cells to 5-bromodeoxyuridine results in a rapid loss of the ability to synthesize the chondroitin 4-sulfate-protein complex characteristic of the extracellular matrix of differentiated cartilage. UDP-glucose dehydrogenase, UDP-N-acetyl hexosamine 4-epimerase and the enzyme system responsible for catalyzing 3′-phosphoadenosine-5′-phosphosulfate synthesis all progressively decline in activity, while several other cellular processes seem unaffected. However, there are marked morphological changes which may be associated with plasma membrane components or the synthesis of the protein-polysaccharide complex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=223532Documentos Relacionados
- EFFECT OF 5-BROMODEOXYURIDINE ON MAMMALIAN CHROMOSOMES*
- The loss of phenotypic traits by differentiated cells, V. The effect of 5-bromodeoxyuridine on cloned chondrocytes.
- Effect of 5-Bromodeoxyuridine on Chromatin Transcription in Confluent Fibroblasts
- Effect of 5-bromodeoxyuridine on heterogeneous nuclear RNA in rat hepatoma cells.
- EFFECT OF 5-BROMODEOXYURIDINE ON THE EXPERIMENTALLY INDUCED RADIORESISTANCE OF ESCHERICHIA COLI