Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus.
AUTOR(ES)
Ofori-Anyinam, O
RESUMO
R 78206 (a pyridazinamine derivative) inhibits the formation of poliovirus eclipse particles. Its effect on the intracellular location of poliovirus was studied by separating subcellular fractions in iso-osmotic Nycodenz gradients. The compound did not inhibit internalization of intact virus into small lipid vesicles, but it did inhibit the release of virus from these vesicles and its entry into lysosomes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240400Documentos Relacionados
- Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound.
- Addition of a foreign oligopeptide to the major capsid protein of poliovirus.
- Chloroquine induces empty capsid formation during poliovirus eclipse.
- Effect of hypertonic medium on protein synthesis of Mahoney and LSc poliovirus.
- Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.