Effect of an Interferon Inducer, 9-Methylstreptimidone, on Candida albicans Infection in Mice

AUTOR(ES)

Umenai, Takusei

RESUMO

The protective effect of an interferon inducer with a low molecular weight, 9-methylstreptimidone (9-MS), against Candida albicans infection in mice was investigated. The antibiotic was effective only when given prophylactically. When administered in such a manner, the growth of C. albicans in the kidneys and brain was inhibited at the initial stage of infection. The growth of C. albicans was not inhibited by the antibiotic in vitro, and no antifungal effect was obtained in a preparation containing induced interferon. These results suggest that the antifungal action of 9-methylstreptimidone in mice might be manifested not by direct antifungal activity but rather by a host-mediated activity that excludes interferon-inducing capability.

Documentos Relacionados

• Lack of Effect of an Interferon Inducer, N,N-Dihexadecyl-m-Xylylenediamine, on Rhinovirus Challenge in Humans
• Effects of an Interferon Inducer, Poly I:C, on Acute Ocular Infection Produced by Intracameral Inoculation of Toxoplasma gondii
• Dipyridamole, as an interferon inducer, versus placebo in the prevention of recurrences of condylomata acuminata after diathermocoagulation.
• Sensitivity of Types 1 and 2 Herpesvirus hominis to an Interferon Inducer, Poly I:C
• Influence of Gonadectomy on Candida albicans Urinary Tract Infection in CFW Mice