Effect of baclofen upon monosynaptic and tonic vibration reflexes in patients with spasticity
AUTOR(ES)
McLellan, D. L.
RESUMO
Measurements of monosynaptic reflex activity were made in 10 patients with spasticity before and during treatment with baclofen. There was evidence of both central sensory facilitation and increased fusimotor drive in untreated patients compared with controls. During treatment with baclofen, the central facilitation was reduced but there was no evidence of a reduction in fusimotor drive. The torque developed by vibration of the belly of the biceps and triceps muscles was not significantly different in 14 patients with spasticity compared with controls, and was not altered by treatment with baclofen despite clinical improvement in 12 of the patients. It is suggested that baclofen reduces the excitability of the monosynaptic reflex arc from dynamic spindles but does not affect the mechanisms responsible for the tonic vibration reflex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=494408Documentos Relacionados
- C0-contraction and stretch reflexes in spasticity during treatment with baclofen.
- Tonic vibration reflex in spasticity, Parkinson's disease, and normal subjects
- Studies on the receptor responsible for vibration induced inhibition of monosynaptic reflexes in man.
- Evidence for a monosynaptic mechanism in the tonic vibration reflex of the human masseter muscle.
- Tonic vibration reflexes elicited during fatigue from maximal voluntary contractions in man.
