Effect of cardiopulmonary bypass on vancomycin and netilmicin disposition.
AUTOR(ES)
Klamerus, K J
RESUMO
The effect of cardiopulmonary bypass (CPB) on the disposition of vancomycin (15 mg/kg) and of netilmicin (3 mg/kg) was studied in 10 adults. The concentration-time profile of the drug in serum and renal clearance were characterized pre-CPB, during CPB, and post-CPB. Vancomycin and netilmicin exhibited initial decreases in mean concentrations in serum of 4.0 mg/liter (16.8%) and 2.2 mg/liter (29.1%), respectively, upon initiation of CPB. Netilmicin concentrations in serum rebounded to a mean of 0.6 mg/liter (15.4%) within 90 min on CPB and then continuously decreased. Vancomycin concentrations in serum demonstrated a rebound increase of 2.3 mg/liter (23.5%) at the end of CPB when the aorta was unclamped. Mean renal clearance throughout CPB was decreased for vancomycin (58.4 to 43.4 ml/min per m2) and netilmicin (53.4 to 31.5 ml/min per m2). The rebound in vancomycin concentration in serum strongly correlated with the length of time between unclamping the aorta and coming off CPB (r = 0.94), as well as with the increase in temperature upon rewarming (r = 0.92).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172243Documentos Relacionados
- Effects of cardiopulmonary bypass surgery on intravenous ciprofloxacin disposition.
- Effect of cardiopulmonary bypass on plasma digoxin concentrations.
- Effect of Surgery and Cardiopulmonary Bypass on Indocyanine Green Pharmacokinetics
- Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol
- Effect of amiloride on metabolic alkalosis and hypokalaemia after cardiopulmonary bypass surgery.
