Effect of diphenylhydantoin on the reproductive function of the male rat.
AUTOR(ES)
Cohn, D F
RESUMO
Male rats were injected with 5, 10, and 20 mg diphenylhydantoin daily for two months and then caged for five days with cyclic females. Thereafter the males underwent necropsy, the organs of the genital tract were examined, and found to be unaffected. Blood testosterone and Leydig cell counts were normal. A significant reduction of fertility was observed which appears to be loss of libido on behavioural grounds. Except for similar behavioural changes described in human epileptics no further reports are available concerning anticonvulsants and fertility. Our findings indicate that there is no reason to suspect that diphenylhydantoin had endocrine-mediated effects on male fertility in the rat.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=493170Documentos Relacionados
- Selective hormonal control of myo-inositol biosynthesis in reproductive organs and liver of the male rat.
- The effects of chronic hypoxia on renal function in the rat.
- Effect of the long-term administration of corticotropin-releasing factor on the pituitary-adrenal and pituitary-gonadal axis in the male rat.
- The effects of systemic hypoxia on renal function in the anaesthetized rat.
- The effect of barium chloride on intestinal secretion in the rat.