Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels.
AUTOR(ES)
Askelöf, P
RESUMO
Dermonecrotic toxin (DNT), lipopolysaccharide (LPS), and lymphocytosis-promoting factor (LPF) were isolated from Bordetella pertussis and tested for neuroactivity. When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect. This action of LPF on the central nervous system was dose dependent and did not require the administration of any additional agent, such as histamine.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551423Documentos Relacionados
- Synergistic effect of Bordetella pertussis lymphocytosis-promoting factor on protective activities of isolated Bordetella antigens in mice.
- In vitro inhibition of murine macrophage migration by Bordetella pertussis lymphocytosis-promoting factor.
- Interaction of Lymphoid and Nonlymphoid Cells with the Lymphocytosis-Promoting Factor of Bordetella pertussis
- Lymphocytosis-promoting factor of Bordetella pertussis alters mononuclear phagocyte circulation and response to inflammation.
- Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis.