Effect of Penicillin on the In Vivo Formation of the d-Alanyl-l-Alanine Peptide Cross-Linkage in Cell Walls of Micrococcus luteus
AUTOR(ES)
Mirelman, David
RESUMO
Penicillin G was found to inhibit the formation of the d-alanyl-l-alanine cross-linkage in intact cells of Micrococcus luteus. This reaction was approximately 50-fold less susceptible to penicillin than the formation of the d-alanyl-l-lysine cross-linkage in the same organism. The presence of two penicillin-susceptible transpeptidation reactions that function in the incorporation of peptidoglycan precursors into the cell wall is proposed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429031Documentos Relacionados
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