Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.
AUTOR(ES)
Brideau, R J
RESUMO
The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Weanling mice infected with a sublethal challenge of CMV exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen concanavalin A. Treatment of mice with pyrimidinones during the course of CMV immunosuppression resulted in substantial augmentation of splenic cell blastogenic responses. The degree of augmentation appeared to be dependent on the severity of CMV-induced immunosuppression.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180288Documentos Relacionados
- Protective effect of biological response modifiers on murine cytomegalovirus infection.
- Immunosuppressive effect of murine cytomegalovirus.
- Protective effect of low-dose interferon against neonatal murine cytomegalovirus infection.
- Effect of Ribavirin on Murine Cytomegalovirus Infection
- Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus.