Effect of renal impairment on distribution of ofloxacin.

AUTOR(ES)

Sanchez Navarro, A

RESUMO

A study was made of the plasma and distribution kinetics of ofloxacin administered at a dosage of 400 mg orally to a group of healthy volunteers and a group of patients with renal impairment. Blood and blister fluid samples were taken at programmed times from all individuals included in the study. The analytical techniques for the determination of ofloxacin in both fluids were a plate diffusion method and a high-performance liquid chromatographic technique. The fitting of the experimental data to the kinetic model used was done with the help of the AUTOAN 2 and NONLIN 84 computer programs. In the groups of healthy volunteers, the elimination half-life mean values were found to be 5.1 and 5.9 h in plasma and blister fluid, respectively. The maximum concentration reached in plasma (3.9 micrograms/ml) proved to be slightly higher than that in interstitial tissue fluid (2.8 micrograms/ml). In the patients with renal impairment, the maximum concentrations in both plasma and blister fluid were significantly increased, in the order of 5 to 8 micrograms/ml in the former and 3 to 4 micrograms/ml in interstitial tissue fluid. The parameters seen to undergo an increase as a result of the renal impairment were the area under the curve of the plasma-time levels, the area under the curve of the blister fluid-time levels, and the elimination half-life in plasma and blister fluid. The degree of absorption and the access capacity of the drug to interstitial tissue fluid remained constant.

Documentos Relacionados

• Effect of sucralfate on absorption of norfloxacin and ofloxacin.
• Effects of two cations on gastrointestinal absorption of ofloxacin.
• Inhibition of DNA gyrase by optically active ofloxacin.
• Synthesis and antibacterial activities of optically active ofloxacin.
• Effects of magnesium-aluminum hydroxide and calcium carbonate antacids on bioavailability of ofloxacin.