Effect of Ribavirin on Murine Cytomegalovirus Infection
AUTOR(ES)
Dowling, John N.
RESUMO
Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide), a new synthetic nucleoside, inhibited murine cytomegalovirus in cell culture. This was shown by the inhibition of viral cytopathic effect and plaque formation, as well as reduction in the yield of virus. Despite this in vitro antiviral effect, ribavirin did not protect mice from mortality produced by a high inoculum of cytomegalovirus. When a lower inoculum was used to initiate a chronic infection, the administration of ribavirin for 9 days had no effect on the titer of cytomegalovirus in the salivary gland, kidney, liver, and spleen. Thus, ribavirin was ineffective in the treatment of both acute and chronic murine cytomegalovirus infections.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429841Documentos Relacionados
- Protective effect of biological response modifiers on murine cytomegalovirus infection.
- Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.
- Effect of murine cytomegalovirus infection on mitogen responses in genetically resistant and susceptible mice.
- Protective effect of low-dose interferon against neonatal murine cytomegalovirus infection.
- Immunosuppressive effect of murine cytomegalovirus.
