Effect of silica on resistance of mice to Entamoeba histolytica infection.
AUTOR(ES)
Ghadirian, E
RESUMO
The role of macrophages in intestinal amoebiasis in mice has been investigated. The effect of injuring host macrophages on the course of infection was examined by using strains selected as being either genetically susceptible (C3H/HeJ, C57BL/6) or genetically resistant (A/J) to amoebiasis. Mice were treated with an intravenous injection of silica particles 1 day before infection with 2.5 X 10(5) or 5 X 10(5) polyxenic trophozoites of Entamoeba histolytica. The animals were killed at various times after infection, and the parasite burden in the cecum was measured. Silica treatment dramatically increased the growth of parasites in the susceptible mice. The same trend was evident, although less marked, in the resistant mice. The effect of silica treatment in experimental amoebiasis was much more pronounced in animals inoculated with 5 X 10(5) amoebae than in those with 2.5 X 10(5) amoebae. These data suggest that macrophages play an important role in host defense against amoebiasis in mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=263236Documentos Relacionados
- Effect of silica on the innate resistance of inbred mice to Salmonella typhimurium infection.
- Effect of nitrogen dioxide on resistance to respiratory infection.
- Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection.
- Amoebic brain abscess: a rare but serious complication of Entamoeba histolytica infection.
- Effect of monophosphoryl lipid A on host resistance to bacterial infection.
