Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
AUTOR(ES)
Monzote Fidalgo, Lianet, Montalvo Álvarez, Ana Margarita, Geigel, Lisset Fonseca, Pérez Pineiro, Rolando, Suárez Navarro, Margarita, Rodríguez Cabrera, Hortensia
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2004-05
RESUMO
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
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