Effect of Trace Metals on Phagocytosis by Alveolar Macrophages
AUTOR(ES)
Graham, Judith A.
RESUMO
Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni2+ selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO3− that caused extensive lysis and death did not reduce phagocytosis in surviving cells. The effects of Cd2+, Cr3+, and Mn2+ on AMs were also examined.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=415211Documentos Relacionados
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