EFFECT OF VACCINES PREPARED FROM HISTOPLASMA CAPSULATUM AND OTHER YEASTS ON EXPERIMENTAL TUBERCULOSIS

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RESUMO

Hedgecock, Loyd W. (Veterans Administration Hospital, Kansas City, Mo.). Effect of vaccines prepared from Histoplasma capsulatum and other yeasts on experimental tuberculosis. J. Bacteriol. 82:115–123. 1961.—Resistance to experimental tuberculosis was enhanced by the injection of a nonviable vaccine prepared from Histoplasma capsulatum in the mycelial phase but not by the organism in the yeast phase. Acquired resistance was established within 7 days or less and usually maintained for at least 29 days. When both mycelium vaccine of H. capsulatum and a vaccine prepared from tubercle bacilli were utilized in vaccination, the results were additive (in terms of acquired resistance) provided that an interval of 3 weeks was maintained between injection of each of the vaccines.

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