Effects of Cetylpyridinium Chloride Resistance and Treatment on Fluconazole Activity versus Candida albicans
AUTOR(ES)
Edlind, Merritt P.
FONTE
American Society for Microbiology
RESUMO
Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=547338Documentos Relacionados
- Effects of Cytokines and Fluconazole on the Activity of Human Monocytes against Candida albicans
- Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans
- Fluconazole versus Candida albicans: A Complex Relationship
- Clonal and Spontaneous Origins of Fluconazole Resistance in Candida albicans
- Effects of amphotericin B and fluconazole on the extracellular and intracellular growth of Candida albicans.
