Effects of cyclosporin on collagen induced arthritis in mice.

AUTOR(ES)

Takagishi, K

RESUMO

We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injection with type II collagen, also resulted in inhibition of development of arthritis and of immunity to collagen. These findings suggest that the time of a booster injection, three weeks after the initial immunisation, might be still within the induction phase of arthritis since reinoculation is required to produce a high incidence of arthritis in mice. In addition, therapeutic treatment with cyclosporin did not affect the clinical course of the disease or the immune response to collagen.

Documentos Relacionados

• Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice.
• Staphylococcal enterotoxin B increases the severity of type II collagen induced arthritis in mice.
• Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice.
• HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis.
• Localization of a critical restriction site on the I-A beta chain that determines susceptibility to collagen-induced arthritis in mice.