Effects of N-cadherin overexpression on the adhesion properties of embryonic stem cells
AUTOR(ES)
Karabekian, Zaruhi
FONTE
Landes Bioscience
RESUMO
Constitutive overexpression of N-cadherin in mouse embryonic stem cells led to marked changes in the phenotype and adhesion properties of these cells. The changes included the formation of smaller embryonic bodies, elevated mRNA and total protein levels of N-cadherin, and increased amounts of p120 catenin and connexin-43. N-cadherin cells exhibited decreased attachment to non-cell surfaces, while their adhesiveness to each other and to rat neonatal cardiomyocytes was significantly elevated. The findings suggest that N-cadherin overexpression can facilitate electromechanical integration of stem cells into excitable tissues with endogenously high levels of N-cadherin, such as the heart and brain.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2712817Documentos Relacionados
- Genomic structure and chromosomal mapping of the mouse N-cadherin gene.
- Inversin Forms a Complex with Catenins and N-Cadherin in Polarized Epithelial Cells
- N-cadherin is regulated by gonadal steroids in the adult hippocampus
- ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling
- Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization