Effects of New Quinolones on Transepithelial Electrical Potential Difference of Tracheal Mucosa In Vivo
AUTOR(ES)
Kanoh, Soichiro
FONTE
American Society for Microbiology
RESUMO
Superfusion of canine tracheal mucosa with 100 μg each of grepafloxacin and ciprofloxacin per ml reduced the electrical transepithelial potential difference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that new quinolones attenuate Cl secretion across the airway epithelium.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90755Documentos Relacionados
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