Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.
AUTOR(ES)
Chan, J
RESUMO
We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and NG-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=173063Documentos Relacionados
- Inducible nitric oxide synthase in Theiler's murine encephalomyelitis virus infection.
- Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors.
- Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control of Mycobacterium tuberculosis in the Murine Lung
- Effects of transition metals on nitric oxide synthase catalysis
- Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis.